Recent Advances in Biodegradable Magnesium Alloys for Medical Implants: Evolution, Innovations, and Clinical Translation

Simple item page
dc.contributor.authorAikin, M.
dc.contributor.authorShalomeev, V.
dc.contributor.authorKukhar, V. V.
dc.contributor.authorKostryzhev, A.
dc.contributor.authorKuziev, I.
dc.contributor.authorKulynych, V.
dc.contributor.authorDykha, O.
dc.contributor.authorDytyniuk, V.
dc.contributor.authorShapoval, O.
dc.contributor.authorZagorskis, A.
dc.contributor.authorBurko, V.
dc.contributor.authorKhliestova, O.
dc.contributor.authorTitov, V.
dc.contributor.authorHrushko, O.
dc.contributor.authorКухар, В. В.
dc.date.accessioned2026-02-24T09:58:45Z
dc.date.issued2025
dc.description.abstractBiodegradable magnesium alloys have emerged as promising alternatives to permanent metallic implants due to their unique combination of mechanical compatibility with bone and complete resorption, addressing the persistent issues of stress shielding and secondary removal surgeries. This review critically examines the historical development of magnesium-based biomaterials, highlighting advances in alloy design, manufacturing processes, and surface engineering that now enable tailored degradation and improved clinical performance. Drawing on recent clinical and preclinical studies, we summarize improvements in corrosion resistance, mechanical properties, and biocompatibility that have supported the clinical translation of magnesium alloys across a variety of orthopedic and emerging medical applications. However, challenges remain, including unpredictable in vivo degradation kinetics, limited long-term safety data, lack of standardized testing protocols, and ongoing regulatory uncertainties. We conclude that while magnesiumbased biomaterials have advanced from experimental concepts to clinically validated solutions, further progress in personalized degradation control, real-time monitoring, and harmonized regulatory frameworks is needed to fully realize their transformative clinical potential.
dc.identifier.citationAikin M., Shalomeev V., Kukhar V., Kostryzhev A., Kuziev I., Kulynych V., Dykha O., Dytyniuk V., Shapoval O., Zagorskis A., Burko V., Khliestova O., Titov V., Hrushko O. Recent Advances in Biodegradable Magnesium Alloys for Medical Implants: Evolution, Innovations, and Clinical Translation. Crystals. 2025. Vol. 15. № 8. 671. DOI: 10.3390/cryst15080671
dc.identifier.citation Aikin, M., Shalomeev, V., Kukhar, V., Kostryzhev, A., Kuziev, I., Kulynych, V., & Hrushko, O. (2025). Recent Advances in Biodegradable Magnesium Alloys for Medical Implants: Evolution, Innovations, and Clinical Translation. Crystals, 15, 8. 671. doi: 10.3390/cryst15080671
dc.identifier.doi10.3390/cryst15080671
dc.identifier.issn2073-4352
dc.identifier.urihttps://dspace.mipolytech.education/handle/mip/3421
dc.language.isoen
dc.publisherMDPI
dc.subjectbiodegradable magnesium alloys
dc.subjectorthopedic implants
dc.subjectcorrosion resistance
dc.subjectsurface engineering
dc.subjectclinical translation
dc.subjectrare-earth-free alloys
dc.subjectadditive manufacturing
dc.subjectregulatory challenges
dc.subjectbiocompatibility
dc.subjectsmart medical devices
dc.titleRecent Advances in Biodegradable Magnesium Alloys for Medical Implants: Evolution, Innovations, and Clinical Translation
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Recent Advances in Biodegradable Magnesium Alloys for Medical Implants: Evolution, Innovations, and Clinical Translation.pdf
Size:
1.71 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
10.29 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Кафедра металургії та інноваційних технологій (МЕТІНТЕХ)